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Here we present the development and practical application of a unique technique, self-organizing map-based prediction of drug equivalence relationships (SPiDER), that merges the concepts of self-organizing maps, consensus scoring, and statistical analysis to successfully identify targets for both known drugs and computer-generated molecular scaffolds. Effectiveness of strontium-89 palliative therapy in patients with painful bone metastases.

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The other 12 were extubated after they had spontaneous breathing (awake extubation). Hip fractures are one of the most serious causes of functional impairment and death in the elderly. Volar percutaneous screw fixation of the scaphoid: a cadaveric study. One area in which evolutionary information can productively be exploited is in aligning a new sequence to a database of existing, aligned genomes. Finally, the fingerprint matching is conducted with the variable bounded box method and iterative strategy.

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Role of acellular dermal matrix-assisted implants in breast reconstruction. Electron transfer pathways within the protein are discussed taking into account possible different locations (cytoplasmatic or periplasmatic) of the iron-sulfur containing protein and their contribution to energy conservation. A scientific paper should have a clear purpose, be organized systematically and target a specific audience. Estimating the onset of cambial activity in Scots pine in northern Finland by means of the heat-sum approach. The technique of fractionating cells by a counter-current distribution procedure in dextran-poly(ethylene glycol) biphasic systems was modified by increasing the settling time and decreasing the top/bottom two-phase volume ratio.

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To detect potential mutations of EDA gene for a Chinese family affected with X-linked hypohidrotic ectodermal dysplasia (XLHED). For each approach, the quality of sensory and motor block was assessed and recorded separately for each of the 4 major nerves of the upper limb.

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The incidence of extrahepatic bile duct carcinoma (EBDC) has been increasing, especially in aged people, but the glycobiology of the tumor is not elucidated. These results demonstrate that housing tenure has a significant impact on labour migration plans in case of unemployment and that the dynamic impact of regional differences in housing affordability on labour mobility is concentrated within the most highly skilled segment of the labour force. To report a case of hemorrhagic gastritis in a patient with chronic renal insufficiency recently initiated on dabigatran etexilate. Baclofen is a g-aminobutyric acid (GABA) derivative that inhibits the production of TLESRs by acting as a GABA(B) receptor agonist at one or more loci along the vagovagal reflex arc.

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Diabetes is an important component of the VA research portfolio. Airway clearance techniques in cystic fibrosis: physiology, devices and the future.

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